The pathophysiology of sepsis
نویسندگان
چکیده
منابع مشابه
Pathophysiology of Sepsis
Background: Sepsis, a systemic inflammatory response to infection, resulting in organ failure and death. Pathogenic microbial agents trigger cascades of events in sepsis by stimulating the host’s immune system. Macrophages require surface receptors to present pathogenic molecule to Toll-like receptors (TLRs) to be activated and release proinflammatory cytokines such as tumour necrosis factor (T...
متن کاملSepsis: Pathophysiology and Treatment
Few pathogens cause sepsis. The majority of sepsis causing bacteria is facultative anaerobes. This type of respiration is the most flexible and it facilitates pathogen survival, proliferation and dissemination in human tissues and blood. Other conditions for causing sepsis are thick slime layer and capsule, as well as production of antioxidant enzymes and substances (superoxide dismutase (SOD),...
متن کاملThe pathophysiology and treatment of sepsis.
From the Departments of Anesthesiology (R.S.H.), Medicine (R.S.H., I.E.K.), and Surgery (R.S.H.), Washington University School of Medicine, St. Louis. Address reprint requests to Dr. Hotchkiss at the Department of Anesthesiology, Washington University School of Medicine, Campus Box 8054, St. Louis, MO 63110, or at [email protected]. epsis is the leading cause of death in critically ill p...
متن کاملThe coagulopathy of sepsis: pathophysiology and management.
Sepsis is an infection-induced inflammatory syndrome that results in a complex network of adaptive and maladaptive alterations in homeostatic mechanisms. Severe sepsis, defined as sepsis associated with acute organ failure, is a serious disease with a mortality rate of 30-50%. The coagulation system, through complex interactions, has an important role in the final outcome of the sepsis-induced ...
متن کاملSepsis: pathophysiology and clinical management.
Sepsis, severe sepsis, and septic shock represent increasingly severe systemic inflammatory responses to infection. Sepsis is common in the aging population, and it disproportionately affects patients with cancer and underlying immunosuppression. In its most severe form, sepsis causes multiple organ dysfunction that can produce a state of chronic critical illness characterized by severe immune ...
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ژورنال
عنوان ژورنال: BJA CEPD Reviews
سال: 2002
ISSN: 1472-2615
DOI: 10.1093/bjacepd/2.1.11